Importance of glial activation in neuropathic pain

神经病理性疼痛 医学 小胶质细胞 神经科学 免疫系统 慢性疼痛 中枢神经系统 伤害 神经炎症 炎症 免疫学 药理学 内科学 生物 受体
作者
Joanna Mika,Magdalena Żychowska,Katarzyna Popiołek-Barczyk,Ewelina Rojewska,Barbara Przewłocka
出处
期刊:European Journal of Pharmacology [Elsevier]
卷期号:716 (1-3): 106-119 被引量:367
标识
DOI:10.1016/j.ejphar.2013.01.072
摘要

Glia plays a crucial role in the maintenance of neuronal homeostasis in the central nervous system. The microglial production of immune factors is believed to play an important role in nociceptive transmission. Pain may now be considered a neuro-immune disorder, since it is known that the activation of immune and immune-like glial cells in the dorsal root ganglia and spinal cord results in the release of both pro- and anti-inflammatory cytokines, as well as algesic and analgesic mediators. In this review we presented an important role of cytokines (IL-1alfa, IL-1beta, IL-2, IL-4, IL-6, IL-10, IL-15, IL-18, TNFalpha, IFNgamma, TGF-beta 1, fractalkine and CCL2); complement components (C1q, C3, C5); metaloproteinases (MMP-2,-9) and many other factors, which become activated on spinal cord and DRG level under neuropathic pain. We discussed the role of the immune system in modulating chronic pain. At present, unsatisfactory treatment of neuropathic pain will seek alternative targets for new drugs and it is possible that anti-inflammatory factors like IL-10, IL-4, IL-1alpha, TGF-beta 1 would fulfill this role. Another novel approach for controlling neuropathic pain can be pharmacological attenuation of glial and immune cell activation. It has been found that propentofylline, pentoxifylline, minocycline and fluorocitrate suppress the development of neuropathic pain. The other way of pain control can be the decrease of pro-nociceptive agents like transcription factor synthesis (NF-kappaB, AP-1); kinase synthesis (MEK, p38MAPK, JNK) and protease activation (cathepsin S, MMP9, MMP2). Additionally, since it is known that the opioid-induced glial activation opposes opioid analgesia, some glial inhibitors, which are safe and clinically well tolerated, are proposed as potential useful ko-analgesic agents for opioid treatment of neuropathic pain. This review pointed to some important mechanisms underlying the development of neuropathic pain, which led to identify some possible new approaches to the treatment of neuropathic pain, based on the more comprehensive knowledge of the interaction between the nervous system and glial and immune cells.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
灵犀发布了新的文献求助10
刚刚
1秒前
1秒前
121212发布了新的文献求助10
1秒前
NexusExplorer应助机灵的煎蛋采纳,获得10
1秒前
酷酷茹嫣发布了新的文献求助10
1秒前
酸化土壤改良应助阻塞阀采纳,获得10
2秒前
非鱼发布了新的文献求助10
2秒前
丘比特应助yuchen12a采纳,获得10
2秒前
2秒前
科目三应助超帅的心锁采纳,获得10
2秒前
3秒前
Akim应助chen采纳,获得10
3秒前
Demon完成签到,获得积分10
3秒前
4秒前
大模型应助雷寒云采纳,获得10
4秒前
cya发布了新的文献求助10
4秒前
5秒前
5秒前
张泽崇应助灵犀采纳,获得10
6秒前
7秒前
7秒前
小二郎应助ma15homes采纳,获得10
7秒前
8秒前
Cker发布了新的文献求助10
8秒前
8秒前
SSSstriker发布了新的文献求助10
10秒前
张zhang发布了新的文献求助10
10秒前
可可发布了新的文献求助10
12秒前
12秒前
脑洞疼应助zhou_AGCT采纳,获得10
12秒前
天上的鱼完成签到,获得积分10
12秒前
华仔应助大可采纳,获得10
12秒前
vanco完成签到,获得积分10
12秒前
糟糕的彩虹完成签到,获得积分10
12秒前
vine发布了新的文献求助10
12秒前
超帅的心锁完成签到,获得积分20
12秒前
宜醉宜游宜睡应助xjl采纳,获得10
12秒前
13秒前
荣仔发布了新的文献求助10
13秒前
高分求助中
Manual of Clinical Microbiology, 4 Volume Set (ASM Books) 13th Edition 1000
Sport in der Antike 800
De arte gymnastica. The art of gymnastics 600
Berns Ziesemer - Maos deutscher Topagent: Wie China die Bundesrepublik eroberte 500
Stephen R. Mackinnon - Chen Hansheng: China’s Last Romantic Revolutionary (2023) 500
Sport in der Antike Hardcover – March 1, 2015 500
Boris Pesce - Gli impiegati della Fiat dal 1955 al 1999 un percorso nella memoria 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2421474
求助须知:如何正确求助?哪些是违规求助? 2111278
关于积分的说明 5344140
捐赠科研通 1838797
什么是DOI,文献DOI怎么找? 915376
版权声明 561171
科研通“疑难数据库(出版商)”最低求助积分说明 489550