肌成纤维细胞
细胞外基质
心肌细胞
电池类型
细胞生物学
人口
免疫学
基质(化学分析)
生物
细胞外
功能(生物学)
病理
细胞
医学
化学
纤维化
遗传学
环境卫生
色谱法
作者
Jennifer Baum,Heather S. Duffy
出处
期刊:Journal of Cardiovascular Pharmacology
[Ovid Technologies (Wolters Kluwer)]
日期:2011-04-01
卷期号:57 (4): 376-379
被引量:382
标识
DOI:10.1097/fjc.0b013e3182116e39
摘要
Cardiac myocytes, although large enough to make up most of the heart volume, are only a minority of cells within the heart with fibroblasts and blood vessel components (endothelial and smooth muscle cells) making up the remainder of the heart. In recent years, there has been increasing interest in the nonmyocyte population within the heart. This is attributable, in part, to our increasing understanding of the biology of the nonmyocyte cell types and additionally it is the result of our awakening realization that these cells are not static but rather that they are dynamic in nature indicating that they play a more active role in cardiac function than previously imagined. Studies now show that fibroblasts are involved in formation of the extracellular matrix and they control the size of the extracellular matrix. Additionally, they participate in the repair process by differentiating into myofibroblasts, which are cells involved in the inflammatory response to injury. Myofibroblasts migrate to the sites of injury where they produce cytokines, thus enhancing the inflammatory response. This review discusses both structural and functional differences between the two cell types and examines the different roles of these two different cell types in the heart.
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