卵巢癌
CD8型
癌症研究
生物
细胞毒性T细胞
干扰素
癌症
癌细胞
免疫学
肿瘤浸润淋巴细胞
淋巴细胞
免疫系统
遗传学
体外
生物化学
作者
Kaoru Abiko,Noriomi Matsumura,Junzo Hamanishi,Naoki Horikawa,Ryusuke Murakami,Ken Yamaguchi,Yumiko Yoshioka,Tsukasa Baba,Ikuo Konishi,Masaki Mandai
摘要
Interferon-γ secreted by CD8-positive lymphocytes upregulates PD-L1 on ovarian cancer cells and promotes tumour growth. The lymphocyte infiltration and the IFN-γ status may be the key to effective anti-PD-1 or anti-PD-L1 therapy in ovarian cancer.
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(2025-6-4)
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