化学
轴对称性
苯甲醛
配体(生物化学)
产量(工程)
苯
药物化学
立体化学
组合化学
有机化学
催化作用
受体
生物化学
结构工程
工程类
材料科学
冶金
作者
Masaaki Omote,Akane Kominato,Michi Sugawara,Kazuyuki Sato,Akira Andõ,Itsumaro Kumadaki
标识
DOI:10.1016/s0040-4039(99)01083-7
摘要
Novel axially dissymmetric ligands (1) with two more chiral carbons were synthesized through homo-coupling of o-bromo-(R or S)-(2,2,2-trifluoro-1-acetoxyethyl)benzene. A high asymmetric induction was accomplished using 5 mol% of the Ti complex of this ligand for the reaction of benzaldehyde with Et2Zn giving 85% ee of 1-phenylpropanol in 97% isolation yield.
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