Abstract We define self-enhancement and self-protection as interests that individuals have in advancing one or more self-domains or defending against negative self-views. We review ways in which people pursue self-enhancement and self-protection, discuss the role of these motivational constructs in scientific explanations, argue for their importance in maintaining psychological and physical well-being, and consider the conditions in which they are likely to operate. At various points, we address the perennial "cognition–motivation" debate. We argue that, despite the conceptual and practical difficulties that attend this distinction, the pervasiveness of the self-enhancement and self-protection motives makes it impossible and imprudent to ignore them in explaining self-related findings and theories.