We define self-enhancement and self-protection as interests that individuals have in advancing one or more self-domains or defending against negative self-views. We review ways in which people pursue self-enhancement and self-protection, discuss the role of these motivational constructs in scientific explanations, argue for their importance in maintaining psychological and physical well-being, and consider the conditions in which they are likely to operate. At various points, we address the perennial “cognition-motivation” debate. We argue that, despite the conceptual and practical difficulties that attend this distinction, the pervasiveness of the self-enhancement and self-protection motives makes it impossible and imprudent to ignore them in explaining self-related findings and theories.