Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene

The inquisitiveness on the use of the BCP motif as a modern lead optimization tactic entails reliable synthetic access. In that direction, we disclose a new and versatile approach to 3-phenylbicyclo[1.1.1]pentan-1-amine, via metal-free homolytic alkylation of benzene.