SPECTROPHOTOMETRIC ANALYSIS OF BOVINE SERUM ALBUMIN IN PRESENCE OF SYNTHESIZED 1-(2’-THIENYL)-3(SUBSTITUTEDPHENYL)--2-PROPEN-1-ONES

ABSTRACT: Serum albumin an important constituent of blood, involved in transportation of a number of compounds interacts with a vast array of chemically diverse ligands, including drugs by various binding sites. Chalcones, 1,3-diaryl propenones have been found to possess diverse pharmacological activities. In the present work we report binding of bovine serum albumin with some chalcones. Series of 1-(2’- thienyl)-3(substitutedphenyl)-2-propen-1-ones were synthesized by the Claisen-Schmidt condensation and their effect was observed on bovine serum albumin. It was found that the synthesized chalcones interacted with bovine serum albumin irrespective of the nature and position of the substituent.