多发性硬化
CD8型
流式细胞术
发病机制
免疫学
外围设备
医学
外周血
干扰素
富马酸二甲酯
复发-缓解
内科学
免疫系统
作者
Laura Negrotto,Ester Cantó,Jordi Río,Mar Tintoré,Xavier Montalbán,Manuel Comabella
标识
DOI:10.1016/j.jneuroim.2015.09.007
摘要
CD8+CD161hi cells, comprising MAIT and non-MAIT cells, have been involved in multiple sclerosis (MS) pathogenesis. Here, we investigated the frequency of CD8+CD161hi, MAIT and non-MAIT cells by flow cytometry in peripheral blood samples from 41 untreated MS patients, 48 patients receiving disease modifying therapies, and 17 healthy controls (HC). IFNβ treatment was associated with a decrease in the frequency of Tc17 cells compared to untreated patients (p=0.019). No significant differences were observed between untreated MS patients and HC for any of the study cell populations. These results suggest previously unknown mechanisms of action of IFNβ.
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