化学
回顾性分析
天然产物
组合化学
分子
产品(数学)
全合成
立体化学
有机化学
几何学
数学
作者
Corinna S. Schindler,Lara Cala,Mario A. Gaviria,Scott L Kim,Trenton R Vogel
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2021-11-22
卷期号:55 (13): 1949-1960
被引量:2
摘要
Abstract The design of concise and efficient synthetic strategies to access naturally occurring, pharmaceutically active complex molecules is of utmost importance in current chemistry. It not only enables rapid access to these molecules and their analogues but also provides sufficient quantities for their biological evaluation. Identification of any symmetric or pseudosymmetric synthetic intermediates upon retrosynthetic bond disconnection of the target molecule holds the promise to significantly streamline the route towards the compound of interest. This review will highlight recent examples of successful natural product syntheses reported within the past five years that benefited from the recognition of symmetry elements during the retrosynthetic design. 1 Introduction 2 Examples 2.1 Chondrosterin I and J 2.2 (–)-Bilobalide A 2.3 Delavatine A 2.4 Oxycodone 2.5 (–)-20-epi-vincamine and (–)-20-epi-eburnamonine 2.6 Reserpine 2.7 (–)-Berkeleyone A 2.8 (–)-Maximiscin 2.9 Aplysiasecosterol A 2.10 (–)-Batrachotoxinin A 2.11 (–)-Mitrephorone A 3 Conclusions
科研通智能强力驱动
Strongly Powered by AbleSci AI