化学
重氮
催化作用
药物化学
终端(电信)
铜
有机化学
沃尔夫重排
环加成
炔烃
作者
Yunhe Lv,Weiya Pu,Xueli Zhu,Chen Chen,Shanshan Wang
标识
DOI:10.1021/acs.joc.1c00789
摘要
An efficient copper-catalyzed three-component 1,1-alkylmonofluoroalkylation of terminal alkynes, diazo compounds, and 2-fluoro-1,3-dicarbonyl compounds for the synthesis of (E)-β-monofluoroalkyl-β,γ-unsaturated esters or ketones has been developed. The methodology features a broad substrate scope, an inexpensive and easily available catalytic system, and excellent selectivity with good yields. The mechanism of the tandem Cu-catalyzed cross-coupling and nucleophilic addition of allenes has been investigated.
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