医学
心脏移植
小RNA
移植
心脏移植物血管病
免疫系统
疾病
生物信息学
生物标志物
重症监护医学
免疫学
病理
内科学
基因
生物化学
化学
生物
作者
Rajat Nog,Chhaya Gupta,Julio A. Panza
出处
期刊:Cardiology in Review
[Ovid Technologies (Wolters Kluwer)]
日期:2021-04-12
卷期号:30 (5): 253-257
被引量:4
标识
DOI:10.1097/crd.0000000000000393
摘要
The need for noninvasive biomarkers for diagnostic, prognostic, and therapeutic purposes is increasingly being recognized in the field of heart transplantation. MicroRNAs are a class of novel biomarkers that control gene expression and influence cellular functions, including differentiation, proliferation, and functional regulation of the immune system. They can be detected in the serum, plasma, and urine and may serve as early noninvasive biomarkers for various disease processes. Despite significant advances in heart transplantation, challenges remain in the short and long term with early graft injury and dysfunction, both cellular and antibody-mediated rejection, infections of varying types and severity, and cardiac allograft vasculopathy, which require an interventional approach for diagnosis and management. In this article, we review the current knowledge on the role of microRNAs in heart transplantation and its related complications and discuss their potential impact in future strategies to manage heart transplantation.
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