泛素连接酶
生物
泛素
细胞内
细胞生物学
抗体
免疫系统
戒指(化学)
胞浆
受体
生物化学
遗传学
酶
化学
基因
有机化学
标识
DOI:10.1016/j.semcdb.2021.11.005
摘要
The cytosolic antibody receptor and RING E3 ligase TRIM21 targets intracellular, antibody-coated immune complexes for degradation and activates the immune system. Here we review how TRIM21 degrades diverse targets and how this activity can be exploited in molecular biology and for the development of new therapeutics. In addition, we compare what is known about TRIM21's mechanism to other TRIM proteins and RING E3 ligases.
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