In order to improve the multi station measurement accuracy of laser tracker, aiming at the problem that the measurement error of laser tracker restricts the transfer accuracy, the compensation method of measurement error of single laser tracker in multi-station measurement is studied in this paper. The compensated coordinate measurement values are substituted into the coordinate transformation model, and the weighted total least square method is used to iteratively solve the transfer parameters. The results are verified by Matlab simulation experiments. The results show that the mean square errors of coordinate points before and after compensation are respectively 0.4358μm and 0.2920μm. The data show that the measurement accuracy of the laser tracker is improved by 30%.