Surviving Sepsis Campaign Guidelines 2021: highlights for the practicing clinician

Highlights of the Surviving Sepsis Campaign 2021 1 ensure they would be applicable in both high-and low-resource settings.Secondly, while remaining intensive care unit (ICU)-focused, the 2021 Guidelines acknowledged the long-term impact of sepsis, including physical, psychological, and mental problems experienced by sepsis survivors and their families.A new section of the Guidelines was developed to address long-term outcomes and goals of care in sepsis, with an expanded patient and public involvement in the panel to provide input on the Guidelines and ensure they were consistent with patient and family needs, values, and preferences for care.In this paper, we outline the noteworthy aspects of each section of the 2021 Guidelines that represent a change from previous practice, address an important clinical question not previously discussed, or remain an area of persistent clinical challenge.