肌氨酸
检出限
化学
交货地点
组合化学
过氧化物酶
纳米技术
色谱法
材料科学
有机化学
酶
生物化学
甘氨酸
氨基酸
农学
生物
作者
Qi Liu,Shoufu Cao,Qiqi Sun,Chuanwang Xing,Wen Gao,Xiaoqing Lu,Xiyou Li,Yang Guangwu,Sirong Yu,Yanli Chen
标识
DOI:10.1016/j.jhazmat.2022.129321
摘要
Although light-responsive nanozyme have been widely used in colorimetric sensing, some limitations such as poor catalytic activity, low detection efficiency, and unclear structure-activity relationships remain unresolved. Herein, we prepared an excellent light-responsive peroxidase (POD) mimic, perylenediimide (PDI-OH) modified SiO2 @TiO2 yolk-shell spheres (SiO2 @TiO2/PDI-OH), based on DFT-assisted design. The experiment and DFT calculation revealed that the enhanced POD-like activity was mainly attributed to a suitable built-in electric field among adjacent PDI-OH molecules on the surface of the SiO2 @TiO2 and the unique yolk-shell structure with more reaction sites of SiO2 @TiO2. Consequently, the highly selective and ultrasensitive detection of H2O2 is achieved with a detection limit (LOD) of 7.6 × 10-8M. Further, the selective detection of sarcosine with LOD of 1.2 × 10-7 M was also achieved by introducing sarcosine oxidase (SOx). This colorimetric assay is successfully applied to selectively detect H2O2 and sarcosine levels in real samples. Controlled response time, anti-interference, and the robustness of the developed colorimetric sensor are the key advantages. And the present work firstly clarifies the effect of PDIs substituents on the POD-like activity of light-responsive nanozymes and provided new guidelines to develop high-performance nanozymes for hazardous substances detection.
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