对映选择合成
化学
串联
分子间力
组合化学
催化作用
结合
还原消去
铜
联轴节(管道)
过渡金属
分子
立体化学
计算化学
有机化学
材料科学
数学分析
数学
冶金
复合材料
作者
Wan Seok Yoon,Won Jun Jang,Woojin Yoon,Hoseop Yun,Jaesook Yun
标识
DOI:10.1038/s41467-022-30286-8
摘要
Abstract Asymmetric construction of C(sp 3 )–C(sp 3 ) bond with good stereocontrol of the two connecting carbon centres retaining all carbon or hydrogen substituents is a challenging target in transition metal catalysis. Transition metal-catalysed reductive coupling of unsaturated π-substrates is considered as a potent tool to expediently develop the molecular complexity with high atom efficiency. However, such an asymmetric and intermolecular process has yet to be developed fully. Herein, we report an efficient strategy to reductively couple two prochiral conjugate alkenes using a copper-catalysed tandem protocol in the presence of diboron. Notably, this transformation incorporates a wide range of terminal and internal enynes as coupling partners and facilitates highly diastereo- and enantioselective synthesis of organoboron derivatives with multiple adjacent stereocentres in a single operation.
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