Progress for the development of antibacterial surface based on surface modification technology

With the increasing requirement for antibacterial surface especially in biomedical apparatus, constructing the new material surface with bactericidal activity for combating the infection caused by multi-resistant microbials possesses great significance. The surface sterilization in traditional way cannot remove the bacteria completely, and new strategy which could kill the bacteria with high efficiency, safety and convenience is urgently needed. In this review, we recapitulate the commonly used approaches about surface modification technology for combating the bacteria on material surface. According to different mechanism of disinfectant, we first list two widely used bactericidal manners on surface, contacting killing and releasing killing, and summarize its characterizations. Then, the antibacterial surface with these killing factors are concluded, and further categorized into the form of covalent polymer brushes coatings and non-covalent supramolecular coatings. Besides, smart responsive surface adjusted by light, pH or salt, and surface morphology structure such as physical puncture are superficially discussed. We hope this review can provide a comprehensive knowledge in preparing for antibacterial surface.