Direct, One‐pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation

Be dazzled by the sequence: The first efficient and general one-pot method for the reductive bisalkylation of lactams/amides with Grignard and organolithium reagents has been developed (see scheme; DTBMP=2,6-di-tert-butyl-4-methylpyridine, Tf=trifluoromethanesulfonyl).