合成子
化学
催化作用
钴
组合化学
基质(水族馆)
纳米技术
立体化学
有机化学
海洋学
地质学
材料科学
作者
Xiaolong Yu,Kehao Chen,Shan Guo,Pengfei Shi,Chao Song,Jin Zhu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2017-09-19
卷期号:19 (19): 5348-5351
被引量:91
标识
DOI:10.1021/acs.orglett.7b02632
摘要
Cobaltacycle synthesis via C-H activation has been achieved for the first time, providing key mechanistic insight into cobalt catalytic chemistry. N-Chloroamides are used as a directing synthon for cobalt-catalyzed room-temperature C-H activation and construction of heterocycles. Alkynes as coupling partners allow convenient access to isoquinolones, a class of synthetically and pharmaceutically important compounds. The broad substrate scope enables a diverse range of substitution patterns to be incorporated into the heterocyclic scaffold.
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