神经炎症
术后认知功能障碍
认知
氧化应激
炎症
医学
神经科学
炎症反应
病理生理学
生物信息学
心理学
重症监护医学
内科学
生物
作者
David Skvarc,Michael Berk,Linda K. Byrne,Olivia Dean,Seetal Dodd,Matthew Lewis,Andrew Marriott,Eileen M. Moore,Gerwyn Morris,Richard Page,Laura J. Gray
标识
DOI:10.1016/j.neubiorev.2017.11.011
摘要
Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with significant clinical, social and financial impacts for patients and their communities. The underlying pathophysiology is becoming increasingly understood, with the role of neuroinflammation and oxidative stress secondary to surgery and anaesthesia strongly implicated. This review aims to describe the putative mechanisms by which surgery-induced inflammation produces cognitive sequelae, with a focus on identifying potential novel therapies based upon their ability to modify these pathways.
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