材料科学
组织工程
生物医学工程
佩多:嘘
聚己内酯
生物相容性
生物电子学
再生医学
纳米技术
脚手架
骨组织
再生(生物学)
干细胞
聚合物
复合材料
图层(电子)
生物传感器
冶金
细胞生物学
生物
医学
遗传学
作者
Donata Iandolo,Akhilandeshwari Ravichandran,Xianjie Liu,Feng Wen,Jerry Kok Yen Chan,Magnus Berggren,Swee‐Hin Teoh,Daniel T. Simon
标识
DOI:10.1002/adhm.201500874
摘要
Bones have been shown to exhibit piezoelectric properties, generating electrical potential upon mechanical deformation and responding to electrical stimulation with the generation of mechanical stress. Thus, the effects of electrical stimulation on bone tissue engineering have been extensively studied. However, in bone regeneration applications, only few studies have focused on the use of electroactive 3D biodegradable scaffolds at the interphase with stem cells. Here a method is described to combine the bone regeneration capabilities of 3D‐printed macroporous medical grade polycaprolactone (PCL) scaffolds with the electrical and electrochemical capabilities of the conducting polymer poly(3,4‐ethylenedioxythiophene) (PEDOT). PCL scaffolds have been highly effective in vivo as bone regeneration grafts, and PEDOT is a leading material in the field of organic bioelectronics, due to its stability, conformability, and biocompatibility. A protocol is reported for scaffolds functionalization with PEDOT, using vapor‐phase polymerization, resulting in a conformal conducting layer. Scaffolds' porosity and mechanical stability, important for in vivo bone regeneration applications, are retained. Human fetal mesenchymal stem cells proliferation is assessed on the functionalized scaffolds, showing the cytocompatibility of the polymeric coating. Altogether, these results show the feasibility of the proposed approach to obtain electroactive scaffolds for electrical stimulation of stem cells for regenerative medicine.
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