The toxicity of selenium and tellurium to Spirulina platensis was investigated with a standard experiment method of evaluating chemicals’ toxic effects on algae.The joint toxicity of selenium and tellurium to S.platensis was assessed with additive index.The results showed that the toxicity effect of Se(IV) on S.platensis was heavier than that of Te(IV).The values of EC50,96h were 125.2 mg/L and 36.1 mg/L,respectively.The joint toxicity was antagonistic,the value of EC50,96h was 103.1 mg/L.