TRPV1-Mediated Physiopathological Mechanisms

The transient receptor potential(TRP)protein family consists of a diverse group of non-selective cation channels.So far,more than 30 family members belonging to the TRP family have been identified and cloned in mammalians.TRPV1 is one of the earliest discovered TRPV subfamily members and is mainly found in peripheral sensory nerves of mammalians.TRPV1 channels can be activated or sensitized by lots of exogenous and endogenous mediators including heat and pain.The main physiological function of TRPV1 is to sense the noxious stimuli.Recent researches show that genesis of inflammation and cough bear a close relationship with the pathological mediation of the TRPV1 channels.