生物分子
光谱学
直接成像
分子成像
纳米技术
显微镜
化学
材料科学
化学物理
物理
光学
生物
量子力学
生物技术
体内
作者
Ji‐Xin Cheng,X. Sunney Xie
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2015-11-27
卷期号:350 (6264)
被引量:632
标识
DOI:10.1126/science.aaa8870
摘要
Vibrational spectroscopy has been extensively applied to the study of molecules in gas phase, in condensed phase, and at interfaces. The transition from spectroscopy to spectroscopic imaging of living systems, which allows the spectrum of biomolecules to act as natural contrast, is opening new opportunities to reveal cellular machinery and to enable molecule-based diagnosis. Such a transition, however, involves more than a simple combination of spectrometry and microscopy. We review recent efforts that have pushed the boundary of the vibrational spectroscopic imaging field in terms of spectral acquisition speed, detection sensitivity, spatial resolution, and imaging depth. We further highlight recent applications in functional analysis of single cells and in label-free detection of diseases.
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