A STUDY OF EFFECT OF PIRACETAM ON PROTCETING MCAO RATS

OBJECTIVE: To investigate the treatment effect of piracetam on acute cerebral infarction.METHOD:middle cerebral artery occlusion(MCAO) of rats according to Zea Longa improvement method.All the rats were divided into experimental group,untreated group and sham-operated group.The experimental group were divided into three subgroups: large dose of piracetam(900mg/kg) group,medium dose of piracetam(600mg/kg) group and small dose piracetam(300mg/kg) group.The experiment observed the neurobehavior of rats,the water content in cerebra,the volume of cerebral infarction and ultramicrostructure.RESULTS:① Large dose of piracetam(≧600mg/kg) significantly increased scores of praxiology(P0.01) 、decreased water content(P0.05) and the expression of Aquaporin(AQP4) in MCAO.②All dose of piracetam decreased volume of ischemic(P0.01) and remained relatively intact ultramicrostructure.CONCLUSION:Large dose of piracetam(≧600mg/kg) are the most effective on protecting acute cerebral infarction.