Research progress in preparation and modification of porous polymeric microspheres for pulmonary drug delivery

As a non-invasive administration method,pulmonary drug delivery displays a great potential in the inhalable delivery of protein and peptide. The porous polymeric microspheres are one of the most suitable carriers for pulmonary drug delivery,this article presents several traditional methods to prepare porous polymeric microspheres,and analyzes the pros and cons of these methods under different conditions in the first place. Then,aiming at those questions such as difficulty to achieve a controllable process,and low efficiency in encapsulating drugs,this article reviews the physical and chemical modification of the porous microspheres to obtain a higher performance by the researchers in recent years,and the advices for the existing problems are also proposed. Finally,the combination of different methods to prepare porous polymeric microspheres for pulmonary drug delivery and their potential applications in the field of biomedicine are prospected.