Objective To explore the diagnosis and treatment of adult Wilms tumor.Methods Data of 3 cases of adult Wilms tumor was analyzed retrospectively and literature was reviewed.Results All patients received radical nephrectomy,adjuvant radiotherapy and chemotherapy postoperatively,and were followed up for 2 to 3 years.The results were satisfactory.Conclusions Adult Wilms tumor is a rare malignant tumor,early and exact diagnosis for which largely depends on radiological and pathological examinations.Combined therapy including radical nephrectomy,chemotheraphy and radiotheraphy can improve the curative rate significantly.