Influence of Jinkuishenqiwan on Mice Myelosuppression Induced by Cyclophosphamide

Objective To study the influence of jinkuishenqiwan on myelosuppression in mice induced by cyclophosphamide. Methods 30 mice were randomly divided into 3 groups: the model control,the jinkuishenqiwan group and the blank control,which were administrated by gavage with jinkuishenqiwan 0.125 mL·d-1,the same volume of distilled water for 10 days,respectively.The model was established by injecting cyclophosphamide for 3 consecutive days at 40 mg·kg-1 daily.Thereafter,the bone marrow hematoplast and bone marrow cell micronucleus were observed and analyzed. Results Jinkuishenqiwan significantly inhibited the decrease of mouse bone marrow hematoplast and the increase of bone marrow cell micronucleus ratio caused by cyclophosphamide(P0.01). Conclusion Jinkuishenqiwan could relieve the mice myelosuppression induced by cyclophosphamide.