The wide immune-tumour relationship is breaking a new standard for nanomedicine expectancy. Besides, Nano medicine provides other benefits as Noval drug delivery system for cancer treatment. Nanomedicine is an interdisciplinary application to provide diverse information for detection and therapy. We can design nanotubules, NPs, nano biosensors to highly sensitive tumour detection via the imaging techniques. These Novals immunomodulating treatments mainly rely on the body own defence system to combat cancer cells. Currently, the researchers concentrate on re-activating immune-stimulatory system to attack cancerous cells with powerful cytokines, vaccines, antibodies and the genes and chemo-therapeutics. Nevertheless, these immunotherapies can exert distinct toxicities as well as adverse effects related to a systemic therapy, poor efficacy and resistance. Then, nanomedicine is an emerging discipline with brilliant prospects on the use of immunomodulating oncology. In this case advance therapeutics strategies are required to further extend the most advanced technique in diagnosing and treating disease, with the basic knowledge for the rational application of currently available cancer treatment modalities. Such nano complexes can penetrate the blood and are capable to target at tumour site through active as well as passive targeting effects. Novel active and passive strategies have evolved to achieve prolongation in systemic circulation with increased bioavailability. Nanotechnology is a relatively novel field and it has huge impacts at both clinical and basic level in medicine because better transportation of high-specific targeted to tumours immune cells, improve clinical results and reduced side-effects which help vaccines delivery immunomodulating agents.