Access to Perfluoroalkenyl Pyrazolo[5,1-a]isoquinolines by Merging [3+2] Annulation with Successive Vicinal C(sp3)-F Bond Cleavage

Successive defluorinative functionalization of multiple C(sp3)-F bonds provides a powerful yet challenging approach to value-added organofluorine compounds. Herein, we report a metal- and oxidant-free defluorinative [3+2] annulation of polyfluoroalkynes with...