基因
DNA甲基化
表观遗传学
生物
异位表达
癌症
图谱
癌症研究
基因表达谱
癌细胞
肾癌
生物信息学
肾细胞癌
基因组
计算生物学
基因表达
遗传学
医学
肿瘤科
蛋白质表达
作者
Su Zhang,Wei Chang,Hao Wu,Yu Han Wang,Yu Gong,You Li Zhao,Shan Hui Liu,Han Zhang Wang,Robert S. Svatek,Ronald Rodríguez,Zhi Ping Wang
摘要
Iron is an essential metal ion in the human body and usually dysregulated in cancers. However, a comprehensive overview of the iron-related genes and their clinical relevance in cancer is lacking. In this study, we utilized the expression profiling, proteomics, and epigenetics from the Cancer Genome Atlas database to systematically characterized the alterations of iron-related genes. There were multiple iron-related genes with dysregulation across 14 cancers and some of these ectopic changes may be associated with aberrant DNA methylation. Meanwhile, a variety of genes were significantly associated with patient survival, especially in kidney renal clear cell carcinoma. Then differentially expressed genes were validated in clinical samples. Finally, we found deferoxamine and erastin could inhibit proliferation in various tumor cells and influence the expression of several iron-related genes. Overall, our study provides a comprehensive analysis of iron metabolism across cancers and highlights the potential treatment of iron targeted therapies for cancers.
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