疟疾
生物
免疫
疟原虫(生命周期)
免疫学
细胞毒性T细胞
恶性疟原虫
T细胞
CD8型
免疫系统
遗传学
寄生虫寄主
万维网
计算机科学
体外
作者
Samarchith P. Kurup,Noah S. Butler,John T. Harty
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2019-04-02
卷期号:19 (7): 457-471
被引量:154
标识
DOI:10.1038/s41577-019-0158-z
摘要
Immunity to malaria has been linked to the availability and function of helper CD4+ T cells, cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage and the symptomatic blood stage of Plasmodium sp. infection. These T cell responses are also thought to be modulated by regulatory T cells. However, the precise mechanisms governing the development and function of Plasmodium-specific T cells and their capacity to form tissue-resident and long-lived memory populations are less well understood. The field has arrived at a point where the push for vaccines that exploit T cell-mediated immunity to malaria has made it imperative to define and reconcile the mechanisms that regulate the development and functions of Plasmodium-specific T cells. Here, we review our current understanding of the mechanisms by which T cell subsets orchestrate host resistance to Plasmodium infection on the basis of observational and mechanistic studies in humans, non-human primates and rodent models. We also examine the potential of new experimental strategies and human infection systems to inform a new generation of approaches to harness T cell responses against malaria.
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