PI3K/AKT/mTOR通路
蛋白激酶B
结直肠癌
依维莫司
MAPK/ERK通路
癌症研究
医学
信号转导
癌症
生物
肿瘤科
内科学
细胞生物学
作者
Afsane Bahrami,Forouzan Amerizadeh,Soodabeh Shahidsales,Hamid Reza Sadeghnia,Mina Maftouh,Seyed Mahdi Hassanian
摘要
ABSTRACT PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown to be related with cellular transformation, tumor progression, cell survival, and drug resistance. There is growing body of data evaluating the value of PI3K/AKT/mTOR inhibitors in CRC (e.g., BEZ235, NVP‐BEZ235, OSI‐027, everolimus, MK‐2206, KRX‐0401, BYL719, and BKM120). This report summarizes the current knowledge about PI3K/AKT pathway and its cross talk with ERK/MAPK and mTOR pathways with particular emphasis on the value of targeting this pathway as a potential therapeutic target in treatment of colorectal cancer. J. Cell. Biochem. 119: 2460–2469, 2018. © 2017 Wiley Periodicals, Inc.
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