Chapter 22. Pharmacokinetics of Multiple Dosing

PreviousNext No AccessHandbook of Basic Pharmacokinetics… Including Clinical Applications, 7th EditionChapter 22. Pharmacokinetics of Multiple Dosinghttps://doi.org/10.21019/9781582121260.ch22 SectionsAboutFull TextReferences ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinkedInRedditEmail Abstract:It is generally recognized that the concentration in blood, plasma, or serum of many drugs must be maintained above a certain minimum throughout the course of therapy to ensure clinical effectiveness. Examples of such drugs are antibiotics, anticoagulants, cytostatics, antidiabetics, hormones, and coronary dilators. However, sometimes fluctuations between high and low levels are preferred; this has been suggested, for instance, for penicillin and other antibiotics with similar mechanisms of action. If a drug is administered in fixed doses and at fixed intervals, accumulation occurs if drug intake exceeds elimination.Selected References1. Doluisio, J. T. and Dittert, C. W.: Influence of Repetitive Dosing of Tetracycline on Biological Half-Life in Serum, Clin. Pharmacol. Ther. 10:690 (1969). Medline, Google Scholar, 2. Dost, F. H.: Grundlagen der Pharmakokinetik, Georg Thieme Verlag, Stuttgart, 1968, p. 169. Google Scholar, 3. Loo, J. C. K. and Riegelman, S.: Assessment of Pharmacokinetic Constants from Postinfusion Blood Curves Obtained After I.V. Infusion, J. Pharm. Sci. 59:53 (1970). Medline, Google Scholar, 4. Ritschel, W. A.: Dose Size and Dosing Interval Determination, Arzneim. Forsch. 25:1442 (1975). Medline, Google Scholar, 5. Ritschel, W. A.: Pharmacokinetics of Multiple Dosing, Dose Size and Dosing Interval, Pharm. Ind. 38:82 (1976). Google Scholar, 6. Schumacher, G. E.: Practical Pharmacokinetic Techniques for Drug Consultation and Evaluation I: Use of Dosage Regimen Calculations, Am. J. Hosp. Pharm. 29:474 (1972). Google Scholar, 7. Wagner, J. G.: Biopharmaceutics and Relevant Pharmacokinetics, Drug Intelligence Publications, Hamilton, Ill. 1971, pp. 22, 242, 270, and 292. Google Scholar, 8. Wagner, J. G.: Significance of Ratios of Different Volumes of Distribution in Pharmacokinetics, Biopharm. Drug Dispos. 4:263 (1983). Google Scholar, PreviousNext Session Activity Recently Viewed Chapter 22. Pharmacokinetics of Multiple Dosing Wolfgang A. Ritschel and Gregory L. Kearns Recently Searched No search history FiguresReferencesRelatedDetails Published: 9 June 2016eISBN: 1-58212-126-5 Copyright & Permissions© 2009 by the American Pharmacists Association. All rights reserved.© 2009 by the American Pharmacists Association. All rights reserved. Publisher American Pharmacists Association HistoryPublished: 9 June 2016 Citation Information (2009), "Chapter 22. Pharmacokinetics of Multiple Dosing," Handbook of Basic Pharmacokinetics… Including Clinical Applications, 7th Edition https://doi.org/10.21019/9781582121260.ch22 Loading ...