乙型肝炎病毒
生物
病毒学
肝细胞癌
病毒
机制(生物学)
基因组
病毒复制
DNA
乙型肝炎
体细胞
发病机制
基因
免疫学
遗传学
哲学
认识论
作者
Thomas Tu,Magdalena A. Budzinska,Nicholas Shackel,Stephan Urban
出处
期刊:Viruses
[MDPI AG]
日期:2017-04-10
卷期号:9 (4): 75-75
被引量:257
摘要
Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and mortality. One peculiar observation in cells infected with HBV (or with closely‑related animal hepadnaviruses) is the presence of viral DNA integration in the host cell genome, despite this form being a replicative dead-end for the virus. The frequent finding of somatic integration of viral DNA suggests an evolutionary benefit for the virus; however, the mechanism of integration, its functions, and the clinical implications remain unknown. Here we review the current body of knowledge of HBV DNA integration, with particular focus on the molecular mechanisms and its clinical implications (including the possible consequences of replication-independent antigen expression and its possible role in hepatocellular carcinoma). HBV DNA integration is likely to influence HBV replication, persistence, and pathogenesis, and so deserves greater attention in future studies.
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