Pin1: a catalyst of the tumorigenesis of malignant neoplasms

Pin1 belongs to peptidyl-prolyl cis-trans isomerase (PPlases) family, which can specif-ically catalyze the phosphorylated Ser/Thr-Pro motif to change its cis-trans isomerism, thereby modulat-ing the conformation and function of substrtates. Previous studies have verified that Pin1 is overexpressed in 38 of 60 tumors, and it participates in many cellular signal pathways and promotes tumorigenesis as a catalyst and an amplifier. Here we make a review about the structure and function of Pin1, and the in-volvement and development in malignant neoplasms. Key words: NIMA-interacting peptidylprolyl isomerase; Pin1; Neoplasms