黑色素
过氧化氢酶
抗氧化剂
谷胱甘肽过氧化物酶
过氧化物酶
生物化学
化学
过氧化氢
活性氧
酶
谷胱甘肽
辣根过氧化物酶
谷胱甘肽还原酶
GPX6型
GPX3型
硫醇
酶分析
细胞色素c过氧化物酶
作者
Gyeongchan Jeon,Chinhan Kim,Min Ju Cho,Ee Taek Hwang,Hyung Ju Hwang,Jiho Min
标识
DOI:10.1007/s12033-020-00292-6
摘要
Melanin is the most important factor to determine skin color. Many research efforts are being undertaken to decompose the already-produced melanin compounds in skin for beauty. This research investigated the effects on reducing melanin color of the three antioxidant enzymes, Glutathione peroxidase (GPX), Thiol peroxidase (TPX), and Catalase, in lysosomal fraction. Melanin solution was treated with the enzymes and hydrogen peroxide, then reacted for 48 h. GPX and TPX decolorized melanin, and between them, GPX was more efficient, but Catalase was not effective. GPX also inhibited the production of melanin in B16F10 melanoma cells. GPX, which is present in almost all microorganisms, plays an important role in the cellular defense mechanism by reactive oxygen species. In addition, it was not cytotoxic, but was significantly effective in decolorizing melanin color. Therefore, in the biological and microbiological field, its possibility of utilization in skin whitening cosmetic is high.
科研通智能强力驱动
Strongly Powered by AbleSci AI