Beyond the unfolded protein response: Disclosing the role of XBP1s in Alzheimer’s disease

In the last 25 years, neuroscientists in search of a cure for Alzheimer’s disease (AD) have devoted their efforts to developing therapeutic strategies targeting the amyloid-β (Aβ) peptide. However, considering the questionable results of the clinical trials so far, it is vital to examine other targets and therapeutic approaches to restore cognitive function in AD patients and to slow down disease progression.