上皮-间质转换
生物
GDF15型
气管狭窄
癌症研究
纤维化
转化生长因子
成纤维细胞
伤口愈合
细胞生物学
狭窄
成纤维细胞生长因子
转化生长因子β
细胞因子
间充质干细胞
背景(考古学)
病理
免疫学
过渡(遗传学)
内科学
内分泌学
医学
体外
受体
基因
古生物学
生物化学
作者
Jiaxin Liao,Yiling Gan,Mingyu Peng,Mohan Giri,Yang Shu,Lei Gu,Anmao Li,Rui Xiao,Chunyan He,Yishi Li,Yang Bai,Li Xu,Shuliang Guo
标识
DOI:10.1016/j.yexcr.2022.113410
摘要
Benign tracheobronchial stenosis (BTS) is a fatal and incurable disease. Epithelial repair and matrix reconstruction play an important role in the wound repair process. If the interstitial context is not restored and stabilized in time, it can lead to pathological fibrosis. Here we attempted to identify cytokines that are involved in promoting wound repair. Growth differentiation factor 15 (GDF15) is a cytokine secreted by tracheal epithelial cells, which is indispensable for the growth of epithelial cells and inhibits the overgrowth of fibroblasts. GDF15 can counteract transforming growth factor-β (TGFβ1) stimulation of epithelial-mesenchymal transition (EMT) in tracheal epithelial cells and inhibit fibroblast activation via the TGFβ1-SMAD2/3 pathway. In a rat model of tracheal stenosis, GDF15 supplementation alleviated the degree of tracheal stenosis. These results suggest that GDF15 prevents fibroblast hyperactivation and promotes epithelial repair in injured trachea. GDF15 may be a potential therapy to improve benign tracheobronchial stenosis.
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