对称化
立体中心
化学
卡宾
硅烷
对映选择合成
对映体药物
催化作用
有机化学
组合化学
硅烷
作者
Hao Liu,Hongwei Zhou,Xingkuan Chen,Jianfeng Xu
标识
DOI:10.1021/acs.joc.2c02184
摘要
An N-heterocyclic carbene (NHC)-catalyzed enantioselective monoesterification of silicon-centered dialdehydes with alcohols or phenols is accomplished, providing optically active organosilanes bearing a stereogenic center at the silicon atom. This desymmetrization protocol is suitable for scale-up synthesis and late-stage modifications of complex molecules, and the products can be further transformed to other enantiopure functionalized silanes.
科研通智能强力驱动
Strongly Powered by AbleSci AI