医学
心房颤动
转甲状腺素
淀粉样变性
淀粉样纤维
心脏淀粉样变性
心脏病学
内科学
纤颤
淀粉样蛋白(真菌学)
病理生理学
疾病
病理
淀粉样β
作者
Syed Bukhari,Syed Zamrak Khan,Zubair Bashir
标识
DOI:10.1016/j.cardfail.2022.08.008
摘要
Cardiac amyloidosis (CA) is caused by extracellular myocardial deposition of amyloid fibrils that are primary derived either from misfolding of transthyretin (ATTR) or light-chain (AL) proteins. CA is associated with atrial fibrillation, potentiated by electromechanical changes as a result of amyloid infiltration in the myocardium. CA also predisposes to thromboembolism and could potentially simultaneously elevate bleeding risk. In this review, we aim to explore and compare the prevalence and pathophysiological mechanisms of atrial fibrillation and thromboembolism in ATTR and AL, examine bleeding risk and factors that promote bleeding, and compare anticoagulation strategies in CA. Finally, we highlight knowledge gaps in the field of thromboembolism in CA to guide future research.
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