金属转移
化学
邻接
电泳剂
炔丙基
烷基
基质(水族馆)
催化作用
硼酸
偶联反应
联轴节(管道)
组合化学
有机化学
工程类
地质学
海洋学
机械工程
作者
Ningxin Xu,Ziyin Kong,Johnny Wang,Gabriel J. Lovinger,James P. Morken
摘要
A neighboring boronate group in the substrate provides a dramatic rate acceleration in transmetalation to copper and thereby enables organoboronic esters to participate in unprecedented site-selective cross-couplings. This cross-coupling operates under practical experimental conditions and allows for coupling between vicinal bis(boronic esters) and allyl, alkynyl, and propargyl electrophiles as well as a simple proton. Because the reactive substrates are vicinal bis(boronic esters), the cross-coupling described herein provides an expedient new method for the construction of boron-containing reaction products from alkenes. Mechanistic experiments suggest that chelated cyclic ate complexes may play a role in the transmetalation.
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