化学
部分
立体化学
电喷雾电离
圆二色性
内酯
质谱法
硫黄
K562细胞
有机化学
体外
生物化学
色谱法
作者
Yu-Chuan Chen,Tong-Mei Xiao,Shuyue Guo,Shanshan Chang,Xiaoming Xi,Bao‐Lian Su,Tao Zhang,Liyan Yu,Wei Zhao,Jing-Shuai Wu,Yan Li,Shuyi Si,Minghua Chen
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-11-21
卷期号:26 (1): 1-5
被引量:1
标识
DOI:10.1021/acs.orglett.3c02958
摘要
Two previous unreported epipolythiodioxopiperazines of the emestrin family, namely, noremestrin A (1) and secoemestrin E (2), were successfully isolated from the fungal source Emericella sp. 1454. Employing comprehensive spectroscopic techniques, such as high-resolution electrospray ionization mass spectrometry, infrared, and nuclear magnetic resonance (NMR), along with NMR and electronic circular dichroism calculations, the chemical structures of compounds 1 and 2 were elucidated. Particularly noteworthy is the distinctive nature of noremestrin A, representing the inaugural instance of a noremestrin variant incorporating a sulfur-bearing 15-membered macrocyclic lactone moiety. Compounds 1 and 2 exhibited weak cytotoxic activities against the human chronic myelocytic leukemia cell lines MEG-01 and K562.
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