Macrophage Membrane‐Modified MoS2 Quantum Dots as a Nanodrug for Combined Multi‐Targeting of Alzheimer's Disease

Abstract The complex pathological mechanism of Alzheimer's disease (AD) limits the efficacy of simple drug therapy, and drugs are difficult to penetrate the blood‐brain barrier (BBB). Therefore, it is a breakthrough to enhance the therapeutic effect of AD by rationally using multiple therapeutic strategies to inhibit multiple pathological targets. In this study, macrophage membrane (MM) with active targeting inflammation function is used to functionalize molybdenum disulfide quantum dots (MoS 2 QDs) with the properties of elimination of reactive oxygen species (ROS) and anti‐A β 1‐42 deposition to form the nano drug (MoS 2 QDs/MM), and play the role of multi‐target combined therapy with NIR. The results show that MoS 2 QDs/MM has a targeted therapeutic effect on ROS elimination and anti‐deposition of A β 1‐42 . In addition, the combined therapy group effectively reduced A β 1‐42 mediated cytotoxicity. The modification of MM could effectively target the brain, and NIR irradiation could actively increase the cross of BBB of materials. In vivo behavioral study also show that APP/PS1 mice in the combined treatment group showed the similar exploration desire and learning ability to mice in the group of WT. MoS 2 QDs/MM is an excellent nano drug with multiple effects, which has advantages in the field of neurological diseases with crisscross pathogenesis.