羧甲基纤维素
自愈水凝胶
生物相容性
流变学
聚合物
化学工程
纤维素
透皮
材料科学
粘弹性
热稳定性
药物输送
高分子化学
组织工程
化学
复合材料
生物医学工程
有机化学
纳米技术
钠
医学
药理学
工程类
作者
Enoch Karolinekersin,S. A. Angayarkanni
标识
DOI:10.1016/j.ijbiomac.2023.127481
摘要
Hydrogels are copiously studied for tissue engineering, drug delivery, and bone regeneration owing to their water content, mechanical strength, and elastic behaviour. The preparation of stable and mechanically strengthened hydrogels without using toxic crosslinkers and expensive approaches is immensely challenging. In this study, we prepared Carboxymethyl cellulose based hydrogels with different polymer concentration via a less expensive physical crosslinking approach without using any toxic crosslinkers and evaluated their mechanical strength. In this hydrogel system, the carbopol concentration was fixed at 1 wt/v% and the Carboxymethyl cellulose concentration was varied between 1 and 5 wt/v%. In this hydrogel system, Carbopol serves as the crosslinker to bridge Carboxymethyl cellulose polymer through hydrogen bonds. Rheological analysis was employed in assessing the mechanical properties of the prepared hydrogel, in particular, the viscoelastic behaviour of the hydrogels. The viscoelastic nature and mechanical strength of the hydrogels increased with an increase in the Carboxymethyl cellulose polymer concentration. Further, our results suggested that gels with Carboxymethyl cellulose concentration between 3 wt/v % and 4 wt/v % with yield stresses of 58.83 Pa and 81.47 Pa, respectively, are potential candidates for use in transdermal drug delivery. The prepared hydrogels possessed high thermal stability and retained their gel network structure even at 50 °C. These findings are beneficial for biomedical applications in transdermal drug delivery and tissue engineering owing to the biocompatibility, stability, and mechanical strength of the prepared hydrogels.
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