妊娠期糖尿病
医学
套式病例对照研究
优势比
内分泌学
内科学
镁
胰岛素抵抗
单核苷酸多态性
糖尿病
怀孕
胃肠病学
基因型
妊娠期
化学
生物
基因
遗传学
生物化学
有机化学
作者
Shanshan Huang,Yanyan Ge,Yan Li,Ningning Cui,Le Tan,Shuyu Guo,Shanshan Wang,Liping Hao,Gang Liu,Xuefeng Yang
标识
DOI:10.1002/mnfr.202200835
摘要
Magnesium plays an important role in regulating glucose metabolism. The study attempts to explore association between magnesium status and single nucleotide polymorphisms (SNPs) of gene involved in magnesium absorption-transient receptor potential membrane melastatin 6 (TRPM6) and gestational diabetes mellitus (GDM) risk METHODS AND RESULTS: A nested case-control study including 170 GDM cases and matched 340 controls is conducted based on Tongji Birth Cohort. Dietary, serum, and urine magnesium are evaluated before the diagnosis of GDM. Compared to the lowest tertile, women in the highest tertile of serum magnesium are at a lower risk of GDM (adjusted odds ratio [aOR] 0.42, 95% confidence intervals [CI] 0.21-0.84). Serum magnesium is inversely associated with insulin and homeostatic model assessment of insulin resistance (β = -0.05, p = 0.002; β = -0.04, p = 0.001, respectively). The aOR for GDM in carriers of the CT or CC genotypes of TRPM6 rs2274924 compared with carriers of the TT genotype is 2.76 (95% CI 1.78-4.26). Dietary magnesium is positively associated with serum magnesium (β = 0.02, p = 0.004), but not with GDM risk.Serum magnesium and the TRPM6 rs2274924 polymorphism are associated with the risk of GDM.
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