神经科学
脊髓
运动皮层
神经调节
皮质脊髓束
刺激
初级运动皮层
锥体束
心理学
医学
磁共振成像
磁共振弥散成像
放射科
作者
Giuliano Taccola,Roger W. P. Kissane,Stanislav Culaclii,Rosamaria Apicella,Wentai Liu,Parag Gad,Ronaldo M. Ichiyama,Samit Chakrabarty,V. Reggie Edgerton
标识
DOI:10.1016/j.expneurol.2023.114589
摘要
Highly varying patterns of electrostimulation (Dynamic Stimulation, DS) delivered to the dorsal cord through an epidural array with 18 independent electrodes transiently facilitate corticospinal motor responses, even after spinal injury. To partly unravel how corticospinal input are affected by DS, we introduced a corticospinal platform that allows selective cortical stimulation during the multisite acquisition of cord dorsum potentials (CDPs) and the simultaneous supply of DS. Firstly, the epidural interface was validated by the acquisition of the classical multisite distribution of CDPs and their input-output profile elicited by pulses delivered to peripheral nerves. Apart from increased EMGs, DS selectively increased excitability of the spinal interneurons that first process corticospinal input, without changing the magnitude of commands descending from the motor cortex, suggesting a novel correlation between muscle recruitment and components of cortically-evoked CDPs. Finally, DS increases excitability of post-synaptic spinal interneurons at the stimulation site and their responsiveness to any residual supraspinal control, thus supporting the use of electrical neuromodulation whenever the motor output is jeopardized by a weak volitional input, due to a partial disconnection from supraspinal structures and/or neuronal brain dysfunctions.
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