[Research progress of acupuncture mediated analgesia via regulating the function of endocannabinoid system].

Endocannabinoid system (ECS), which composed of its ligands and receptors, widely distributes in peripheral tissues and nerve system. Through complex regulating mechanisms, ECS exerts a variety of biological functions including analgesia. Its utility in analgesic regulation has attracted extensive attention, and the related achievements have also been transformed into clinical practice. With the deepened understanding of the essence of pain, as well as the advances in research techniques, quantity of research evidences showed that ECS could be regulated by acupuncture treatment and exerted analgesic effect in inflammatory pain, neuropathic pain and other related diseases, and the mechanism had also been revealed gradually. By reviewing literatures related to acupuncture analgesia and ECS, we summarized the effect and mechanism of acupuncture analgesia involved with regulation of ECS, pointed out cannabinoid (CB) 1 receptor and CB2 receptor exerted analgesic effect in central and peripheral neural system through mechanisms of inhibiting neural activation and anti-inflammation, respectively. Therefore, we hope to provide reference and inspiration for relevant research and clinical practice in the future.内源性大麻素（ECS）及其受体构成的系统广泛分布于外周组织及神经系统，可通过复杂的调控机制行使包括镇痛在内的多种生物学功能，其镇痛效用受到医学界广泛关注，相关研究成果已进入临床转化阶段。近年来，随着疼痛相关知识体系的完善及研究技术的发展，大量研究证据表明ECS系统可受针刺治疗调控，并在炎性痛、神经病理性疼痛等多种不同类型疾病中发挥镇痛作用，其在外周与中枢神经系统的镇痛调控机制也被逐渐揭示。本文通过回顾针刺镇痛与ECS系统的相关文献，分析总结了涉及ECS的针刺镇痛效应机制，其中大麻素（CB）1受体与CB2受体分别在中枢与外周神经系统通过抑制痛觉相关神经活化与抗炎等方式介导镇痛，为未来相关的科研探索与针刺镇痛的临床实践提供参考和启发。.