生物
背景(考古学)
内质网
未折叠蛋白反应
信号转导
神经科学
神经系统
发病机制
中枢神经系统
细胞生物学
癌症研究
免疫学
古生物学
作者
Francesca Sardina,Andrea Conte,Simona Paladino,Giovanna Maria Pierantoni,Cinzia Rinaldo
标识
DOI:10.1016/j.bbamcr.2023.119465
摘要
HIPK2 is an evolutionary conserved serine/threonine kinase with multifunctional roles in stress response, embryonic development and pathological conditions, such as cancer and fibrosis. The heterogeneity of its interactors and targets makes HIPK2 activity strongly dependent on the cellular context, and allows it to modulate multiple signaling pathways, ultimately regulating cell fate and proliferation. HIPK2 is highly expressed in the central and peripheral nervous systems, and its genetic ablation causes neurological defects in mice. Moreover, HIPK2 is involved in processes, such as endoplasmic reticulum stress response and protein aggregate accumulation, and pathways, including TGF-β and BMP signaling, that are crucial in the pathogenesis of neurological disorders. Here, we review the data about the role of HIPK2 in neuronal development, survival, and homeostasis, highlighting the implications in the pathogenesis of neurological disorders, and pointing out HIPK2 potentiality as therapeutic target and diagnostic or prognostic marker.
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