表观遗传学
表观基因组
生物
DNA甲基化
遗传异质性
遗传学
表型
基因
生物信息学
癌症研究
基因表达
作者
Ryan A. Hlady,Xia Zhao,Louis Y. El Khoury,Ryan T. Wagner,Aesis Luna,Kien Pham,Nikolaos T. Pyrosopoulos,Dhanpat Jain,Liguo Wang,Chen Liu,Keith D. Robertson
出处
期刊:Hepatology
[Lippincott Williams & Wilkins]
日期:2024-07-19
卷期号:81 (4): 1197-1210
被引量:11
标识
DOI:10.1097/hep.0000000000001023
摘要
Substantial epigenetic heterogeneity arises early in liver disease development, targeting key pathways in the progression and initiation of both cirrhosis and HCC. Integration of epigenetic and transcriptional heterogeneity unveils putative epigenetic regulators of hepatocarcinogenesis.
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